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2 and additional Table 3). In addition, we confirmed the presence of the aberrant transcription / alternatives for 112 genes with splice site mutations of RNA from canonical data seq (Supplementary Table 4). We observed an average non-synonymous mutation rate of 2.8 mutations per 106 bases (31 coding region mutations in 55 samples) for SMS samples and 47 mutations per 106 bases (764 coding mutations in the region 15 samples) for the samples MSI in accordance with defective MMR in the latter (Fig.
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